From their website:
The Skeptics' Guide to the Universe is produced by SGU Productions, LLC - dedicated to promoting critical thinking, reason, and the public understanding of science through online and other media. The first episode of the SGU podcast went online on May 4th, 2005. It soon became a popular science/skeptical podcast, and remains one of the most popular science podcasts on iTunes.
The Skeptics' Guide to the Universe is a very fun, entertaining, and thought-provoking podcast. At NECSS, I was able to listen to this podcast live and ask a question to the panel!
I asked a question regarding the ethical responsibilities of skeptics at 1:10:00 in this podcast.